Making way for the pair were Brazilian midfielder Fabio Rochemback and his Argentine team-mate Julio Arca who did not even feature among the substitutes.
However Southgate insisted that Arca is still very much part of his plans.
"I felt with Julio he just needs that break from the team. He's a fantastic player, he's very much with us and he understands why I left him out," he said.
"Today I felt it was just right to change that midfield."