Droylsden can only reach a maximum of 37 points if they win all five remaining games.
They join fellow strugglers Stafford, who were relegated on Tuesday after losing 4-0 at home to York.
In similar circumstances in 2004, Wycombe manager Tony Adams did not realise his club had already been relegated, as he believed they could stay up if they won their remaining games - but some of their relegation rivals still had to play each other.