Calzaghe is unbeaten in 45 contests and a fight with Jones, possibly in Las Vegas, would likely be the Welshman's career swansong.
The Newbridge-based Calzaghe is currently big box office in the United States following his points win - and debut at light-heavyweight - over Bernard Hopkins in Las Vegas in April.
At the end of June, Calzaghe split with long-term promoter Frank Warren saying he would now manage himself.
Announcing the split with Warren in his newspaper column, Calzaghe said: "My intention is to fight Roy Jones Jr, a four-weight world champion fighter.
"That would be a special event for me against a legend of the sport."